Toxic nephropathy (DC 7535)

Body system: Genitourinary SystemRegulation: 38 CFR § 4.115b

DC 7535 covers toxic nephropathy — kidney damage caused by exposure to nephrotoxic agents. Common causes include nephrotoxic antibiotics (aminoglycosides like gentamicin and tobramycin, vancomycin, amphotericin B, polymyxins), iodinated radiocontrast agents (contrast-induced nephropathy), chronic NSAID use (ibuprofen, naproxen, aspirin), heavy metals (lead, cadmium, mercury, arsenic), and other industrial or environmental toxins. Toxic exposures during military service — burn pit smoke, contaminated water (Camp Lejeune), depleted uranium, jet fuel components — can also produce toxic nephropathy. The VA rates this condition under the renal dysfunction ladder (38 CFR § 4.115a) from 0% to 100% based on GFR sustained over 3 consecutive months in the past 12 months.

Rating levels

  • 100% — You qualify for 100% if your toxic nephropathy has progressed to end-stage renal disease — GFR under 15 mL/min/1.73 m² sustained for 3+ consecutive months, OR routine dialysis dependence, OR transplant eligibility.
  • 80% — You qualify for 80% if your toxic nephropathy has progressed to Stage 4 CKD — GFR 15-29 mL/min/1.73 m² sustained for 3+ consecutive months.
  • 60% — You qualify for 60% if your toxic nephropathy is at Stage 3b CKD — GFR 30-44 mL/min/1.73 m² sustained for 3+ consecutive months.
  • 30% — You qualify for 30% if your toxic nephropathy is at Stage 3a CKD — GFR 45-59 mL/min/1.73 m² sustained for 3+ consecutive months.
  • 0% — You qualify for 0% if your GFR is 60-89 mL/min/1.73 m² (Stage 2 CKD) AND you have one of three additional markers sustained for 3+ consecutive months: recurrent urinary casts, structural kidney abnormalities, or proteinuria with ACR ≥ 30 mg/g.

Disclaimer: This tool is for informational purposes only and is not legal or medical advice. Always consult with your VSO representative or a qualified veterans benefits attorney for guidance on your specific claim.